منابع مشابه
Cognition in CADASIL.
CADASIL is an early onset small vessel disease and genetic variant of pure subcortical ischemic vascular dementia (SIVD). The condition has been invaluable in defining the profile and neuroimaging correlates of cognitive deficits in pure SIVD. The recent completion of a randomized trial in cognitively impaired CADASIL patients has illustrated the feasibility of targeted therapeutic trials in na...
متن کاملCadasil.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is the most common heritable cause of stroke and vascular dementia in adults. Clinical and neuroimaging features resemble those of sporadic small-artery disease, although patients with CADASIL have an earlier age at onset of stroke events, an increased frequency of migraine with aura, and a slig...
متن کاملEnhanced rapid-onset cortical plasticity in CADASIL as a possible mechanism of preserved cognition.
Ischemic small vessel disease (SVD) may lead to cognitive impairment, but cognitive deficits with a given burden of SVD vary significantly. The underlying mechanisms of impaired or preserved cognition are unknown. Here, we investigated the impact of ischemic SVD on rapid-onset cortical plasticity, as induced with a paired-associative stimulation protocol. To exclude concomitant effects of aging...
متن کاملNeuropsychiatric manifestations in CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small-artery disease of mid-adulthood caused by mutations of the NOTCH3 gene. The disease is responsible for widespread white-matter lesions associated with lacunar infarctions in various subcortical areas. The disease is responsible for migraine with aura and ischemic strokes, a...
متن کاملDiffusion histograms in CADASIL.
See related article, pages 2559–2565 Diffusion MRI is a unique tool to investigate the microstructure of cerebral tissue. Diffusion-driven displacements of water molecules can probe the tissue architecture at a microscopic scale well beyond the usual image resolution.1 Diffusion is a 3D process. In cerebral white matter, where the movements of water molecules are maximal along the bundles of ax...
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ژورنال
عنوان ژورنال: Stroke
سال: 2008
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.108.534412